Cem anos do relatório Flexner

CEM-T4 Cells Do Not Lack an APOBEC3G Cofactor

Human APOBEC3G inhibits the replication of Vif-deficient HIV-1 by hypermutating nascent viral cDNA (reviewed in [1– 3]). Zheng and colleagues recently reported that the HIV-1 restriction activity of APOBEC3G requires a cellular co-factor [4]. Their conclusion depended on three critical observations: i) CEM-T4 cells support the replication of Vif-deficient HIV-1, ii) CEM-T4 cells express restric...

Abraham Flexner and medical education.

The Flexner Report had its roots in the recognition in the mid-19th century that medical knowledge is not something fixed but something that grows and evolves. This new view of medical knowledge led to a recasting of the goal of medical education as that of instilling the proper techniques of acquiring and evaluating information rather than merely inculcating facts through rote memorization. Ab...

106 Cem

Correspondence: Cem Yasar Sanhal e-mail: cemsanhal@ yahoo.com Objective. To compare the efficacy of five adhesions barrier products with a control group in a rat model. Methods. In this randomized controlled animal study, standardized lesions on parietal peritoneum of rats were created by sandpaper and three interrupted sutures. Afterwards, the lesions were treated with Seprafilm, Interceed, Pr...

Simon Flexner, 1911

Evolução dos Temas de Interesse do SBBD ao Longo dos Anos

A mineração temporal de textos (temporal text mining TTM) é uma técnica cujo objetivo é descobrir a estrutura latente e padrões temporais em coleções de texto. Estas características são importantes em coleções em que os tópicos de interesse mudam frequentemente com o passar do tempo. Além disso, a mineração temporal de textos é útil em ferramentas de sumarização e descoberta de tendências. Nest...